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KMID : 0370219980420030319
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Yakhak Hoeji
1998 Volume.42 No. 3 p.319 ~ p.323
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Inhibition of Immediate Allergic Reaction by Cryptotympana atrata
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신태용/Shin TY
김성화/김형민/Kim SH/Kim HM
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Abstract
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Effects of the aqueous extract of Cryptotympana atrata Fabricius (CAF) on the allergic reactions were investigated. In the present study, we examined the effect of CAF on compound 48/80-induced anaphylaxis in vivo and histamine release from rat peritoneal mast cells in vitro. CAF dose-dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. CAF significantly inhibited serum histamine levels induced by compound 48/80. CAF also inhibited histamine release from the rat peritoneal mast cells activated by compound 48/80. These results suggest that CAF may be useful for the prevention and treatment of allergy related disease.
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